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1.
Mansoura Medical Journal. 2007; 38 (3-4): 245-261
in English | IMEMR | ID: emr-84173

ABSTRACT

Postmenopause was correlated with atherosclerosis. The aim of the study was to evaluate endothelial cell dysfunction by carotid intimal- medial thickness [IMT] and correlate it, using recently available plasma markers nitric oxide [NO], E-selectin, Nuclear factor kappa B [NF-kB]. Case control study. Mansoura university and private clinic. The work was conducted on 15 postmenopausal women with age mean 62.55 +/- 6.68 and 10 premenopausal women with age mean 43.2 +/- 2.53 as a control group. All cases were subjected to complete clinical examination, carotid artery intimal-medial thickness [IMT] measurement by ultrasonography scanning and study of selected plasma markers of endothelial dysfunction nitric oxide [colorimetric method], E selectin [ELISA] and [NF-kB] [immunocytochemistry]. In addition to plasma lipid [colorimetric method]. There was significant [p=0.003] increase in the IMT in post-menopausal women in comparison to the control group. The lipid profile showed significant increase in triglycerides [TG] [p=0.001] and total cholesterol [p=0.013] and significant decrease in HDL-C [p=0.02] in postmenopausal women in comparison to the control group. The nitric oxide [NO] level was significantly lower in post menopausal women compared with control group [p=0.015]. The plasma E-selectin level was elevated in postmenopausal versus with the control group [p=0.03]. NF-kB was significantly increased in post-menopausal women in comparison to control group [P<0.01]. IMT was positively correlated significantly with total cholesterol [p=0.009], LDL-C [p=0.02] and NF-kB [p=0.000] and negatively correlated with HDL-C [p=0.001]. NF-kB was correlated positively with age [p=0.016], total cholesterol [p=0.005], LDL-C [p=0.012] and negatively correlated with HDL-C [p=0.026] and NO [p=0.004]. The present data are in Keeping with the evidence for significant endothelial cell dysfunction, increased IMT, decreased NO in postmenopausal women


Subject(s)
Humans , Female , Endothelium, Vascular , Nitric Oxide , E-Selectin , NF-kappa B , Enzyme-Linked Immunosorbent Assay , Carotid Arteries/diagnostic imaging , Triglycerides , Cholesterol
2.
Journal of the Egyptian Society of Parasitology. 2005; 35 (3): 989-1007
in English | IMEMR | ID: emr-72386

ABSTRACT

The LC50 [78, 85 ppm] and LC90 [88, 135 ppm] of Anagalis arvensis and calendula micrantha respectively against Biomphalaria alexandrina were higher than those of the non-target snails, Physa acuta, Planorbis planorbis, Helisorna duryi and Melanoides tuberculata. In contrast, the LC50 of Niclosamide [0.11 ppm] and Copper sulphate [CuSo4] [0.42 ppm] against B. alexandrma were lower than those of the non-target snails. The mortalities percentage among non-target snails ranged between 0.0 and 20% when sublethal concentrations of CuSo4 against B. alexandrina mixed with those of C. micrantha and between 0.0 and 40% when mixed with A. arvensis. Mortalities ranged between 0.0 and 50% when Niclosamide was mixed with each of A. arvensis and C. micrantha. A. arvensis induced 100% mortality on Oreochromis niloticus after 48 hrs exposure and after 24 hrs for Gambusia affinis. C. micrantha was non-toxic to the fish. The survival rate of O. niloticus and G. affinis after 48 hrs exposure to 0.11 ppm of Niclosamide were 83.3% and 100% respectively. These rates were 91.7% and 93.3% respectively when each of the two fish species was exposed to 0.42 ppm of CuSo4. Mixture of sub-lethal concentrations of A. arvensis against B. alexandrina and those of Niclosamide or CuSo4 at ratios 10:40 and 25:25 induced 66.6% mortalities on O. niloticus and 83.3% at 40: 10. These mixtures caused 100% mortalities on G. affinis at all ratios. A. arvensis CuSo4 mixtures at 10:40 induced 83.3% and 40% mortalities on O. niloticus and G. affinis respectively and 100% mortalities on both fish species at ratios 25:25 and 40:10. A mixture of sub-lethal concentrations of C. micrantha against B. alexandrina and of Niclosamide or CuSo4 caused mortalities of O. niloticus between 0.0 and 33.3% and between 5% and 35% of G. affinis. The residue of Cu in O. niloticus were 4.69, 19.06 and 25.37 mg/ l kgm fish after 24, 48 and 72 hrs exposure to LC0 of CuSO4 against B. alexandrina respectively


Subject(s)
Fishes , Snails , Fresh Water , Calendula/toxicity , /toxicity , Plant Preparations , Niclosamide/toxicity , Biomphalaria , Mortality
3.
Egyptian Journal of Schistosomiasis and Infectious and Endemic Diseases. 2003; 25: 53-65
in English | IMEMR | ID: emr-61839

ABSTRACT

The effect of plants Anagallis arvensis, Calendula micrantha and Ambrosia maritima and the synthetic chemical molluscicides bayluscide and copper sulphate on survivorship, egg production of the snail vectors of schistosomiasis [Biomphalaria alexandrina] and fascioliasis [Lymnaea natalensis] and on some fresh water organisms were studied. Anagallis arvensis and Calendula micrantha showed good molluscicidal action against B. alexandrina and L. natalensis where LC90 values were 88 and 93 ppm, respectively, for A. arvensis and 135 and 100 ppm, respectively, for Calendula micrantha. The cumulative mortality of B. alexandrina [70%] was considerably high after 4 weeks of continuous exposure to A. arvensis. Complete inhibition of egg production was obtained for B. alexandrina after 2 weeks of exposure to low concentration of C. micrantha, bayluscide and copper sulphate. A. arvensis increased the maximum standing crops of algal biomass of Sirogyra [1.1358 g] and daily specific growth rate [0.0586 g.], while the control was 1.0106 g. and 0.0503 g., respectively. A low toxic effect on Daphnia pula was obtained under the effect of Anagul1is arvensis [5% mortality] and calendula micrantha [25% mortality] compared with synthetic molluscicides suggesting the use of the tested plants as molluscicides


Subject(s)
Plant Extracts/isolation & purification , Biomphalaria , Lymnaea , Snails , Environmental Pollutants , Schistosomiasis/parasitology , Fascioliasis/parasitology
4.
Egyptian Journal of Schistosomiasis and Infectious and Endemic Diseases. 2003; 25: 77-92
in English | IMEMR | ID: emr-61841

ABSTRACT

The snails Biomphalaria alexandrina and Lymnaea natalensis were exposed to 1/10 LC50 of copper sulphate or of the plants Anagallis arvensis, Calendula micrantha and Ambrosia maritima. The snails were exposed firstly to copper sulphate then to each of the tested plants and vice-versa. The results showed that the pre-exposure of snails to A. arvensis and C. micrantha plants increased the molluscicidal action of copper sulphate against B. alexandrina and L. natalensis where it caused an additive effect. The pre-exposure to A. maritima caused different effects with copper sulphate, where it showed antagonistic effect on B. alexandrina and additive effect on L. natalensis snails. The pre-exposure of snails to copper sulphate increased the molluscicidal action of the tested plants against B. alexandrina and L. natalensis where it caused synergistic effect in case of Anagallis arvensis and Calendula micrantha against L. natalensis and additive effect in the rest of the treatments. Mixing of copper sulphate with each of the tested plants at different ratios caused antagonism in the molluscicidal activity of copper sulphate against B. alexandrina and L. natalensis snails. The addition of each of the following adjuvants; mono-ethylene glycol mono-oleate, mono-ethylene glycol di-oleate, potassium di-hydrogen phosphate and KZ mineral oil to copper sulphate increased the molluscicidal activity of copper sulphate against B. alexandrina, where it caused synergistic effect. In case of L. natalensis, mono-ethylene glycol mono-oleate and mono-ethylene glycol di-oleate caused an additive effect; while, potassium di-hydrogen phosphate and KZ mineral oil induced antagonistic effect. The result of examination of the toxic effect of copper sulphate in combination with each of the tested adjuvant against Daphnia pulex indicated that the treatment of copper sulphate and mono-ethylene glycol di-oleate increases the molluscicidal activity of copper sulphate and at the same time reduces its toxic effect against non-target organisms [Daphnia] and is the best for application


Subject(s)
Lymnaea/drug effects , Plant Extracts , Daphnia , Molluscacides , Environmental Pollution
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